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CACNA1H (Voltage-dependent T-type calcium channel subunit alpha-1H) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes clinical 0.87, literature 0.88, genetic association 0.00, somatic mutation 0.18, animal model 0.57).
In plain words · CACNA1H (Voltage-dependent T-type calcium channel subunit alpha-1H) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
CACNA1H (Voltage-dependent T-type calcium channel subunit alpha-1H) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group.
No product in this corpus aims at CACNA1H yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA CACNA1H: RNA tissue enhanced (intestine 103 nTPM); high antibody staining in 1 normal tissue. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas CACNA1H tissue; Open Targets ENSG00000196557 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Cribbs L.L. et al, Circ. Res, 1998, "Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family". Source.
Sources: HGNC HGNC:1395 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95180 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196557 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signalling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signalling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia. Location: Cell membrane (UniProt). Locus 16p13.3 (HGNC).
RNA: tissue enhanced (intestine 103 nTPM), detected in many normal tissues.
Medium: Adrenal gland, Bronchus, Esophagus, Fallopian tube, Gallbladder, Lung, Nasopharynx, Ovary.
No cancer stained high; medium in breast cancer, endometrial cancer, lymphoma, melanoma.
HPA CACNA1H tissue · HPA CACNA1H pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CACNA1H" OR ABSTRACT:"CACNA1H" OR TITLE:"calcium voltage-gated channel subunit alpha1 H" OR ABSTRACT:"calcium voltage-gated channel subunit alpha1 H" OR TITLE:"Voltage-dependent T-type calcium channel subunit alpha-1H" OR ABSTRACT:"Voltage-dependent T-type calcium channel subunit alpha-1H" OR TITLE:"Cav3.2" OR ABSTRACT:"Cav3.2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CACNA1H, not a curated reading list.