{"entity":{"id":"cacna1h","kind":"target","name":"CACNA1H","aka":["calcium voltage-gated channel subunit alpha1 H","Voltage-dependent T-type calcium channel subunit alpha-1H","Cav3.2"],"tldr":"CACNA1H (Voltage-dependent T-type calcium channel subunit alpha-1H) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes clinical 0.87, literature 0.88, genetic association 0.00, somatic mutation 0.18, animal model 0.57).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1395","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1395"},{"label":"UniProt O95180","url":"https://www.uniprot.org/uniprotkb/O95180/entry"},{"label":"NCBI Gene 8912","url":"https://www.ncbi.nlm.nih.gov/gene/8912"},{"label":"Ensembl ENSG00000196557","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196557"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.87. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CACNA1H","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:1395","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1395","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O95180","url":"https://www.uniprot.org/uniprotkb/O95180/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000196557","url":"https://platform.opentargets.org/target/ENSG00000196557/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA CACNA1H: RNA tissue enhanced (intestine 103 nTPM); high antibody staining in 1 normal tissue. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas CACNA1H tissue","url":"https://www.proteinatlas.org/ENSG00000196557-CACNA1H/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000196557 associations","url":"https://platform.opentargets.org/target/ENSG00000196557/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:1395","ensembl":"ENSG00000196557","uniprot":"O95180","entrez":"8912","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Cribbs L.L. et al, Circ. Res, 1998, \"Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9670923/","biology":"Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signalling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signalling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia. Location: Cell membrane (UniProt). Locus 16p13.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/cacna1h/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}