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BIRC7 (Baculoviral IAP repeat-containing protein 7) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Cisplatin.
In plain words · BIRC7 (Baculoviral IAP repeat-containing protein 7) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
BIRC7 (Baculoviral IAP repeat-containing protein 7) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control.
No product in this corpus aims at BIRC7 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA BIRC7: RNA tissue enhanced (placenta 6 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas BIRC7 tissue; Open Targets ENSG00000101197 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Lin J.-H. et al, Biochem. Biophys. Res. Commun, 2000, "KIAP, a novel member of the inhibitor of apoptosis protein family". Source.
Sources: HGNC HGNC:13702 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96CA5 (protein name, function text, keywords and locations (REST API)); CIViC gene BIRC7 (2 evidence items, 0 assertions, 1 variants; diseases: Colon Cancer, Papillary Thyroid Carcinoma (GraphQL API, CC0))
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. Location: Nucleus; Cytoplasm; Golgi apparatus (UniProt). Locus 20q13.33 (HGNC).
RNA: tissue enhanced (placenta 6 nTPM), detected in some normal tissues.
No normal tissue stained high.
RNA cancer enriched: Skin Cutaneous Melanoma 145 pTPM.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"BIRC7" OR ABSTRACT:"BIRC7" OR TITLE:"baculoviral IAP repeat containing 7" OR ABSTRACT:"baculoviral IAP repeat containing 7" OR TITLE:"Baculoviral IAP repeat-containing protein 7" OR ABSTRACT:"Baculoviral IAP repeat-containing protein 7" OR TITLE:"mliap" OR ABSTRACT:"mliap" OR TITLE:"ML-IAP" OR ABSTRACT:"ML-IAP" OR TITLE:"RNF50" OR ABSTRACT:"RNF50") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BIRC7, not a curated reading list.