{"entity":{"id":"birc7","kind":"target","name":"BIRC7","aka":["baculoviral IAP repeat containing 7","Baculoviral IAP repeat-containing protein 7","mliap","ML-IAP","RNF50"],"tldr":"BIRC7 (Baculoviral IAP repeat-containing protein 7) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.","summary":"Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Cisplatin.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13702","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13702"},{"label":"UniProt Q96CA5","url":"https://www.uniprot.org/uniprotkb/Q96CA5/entry"},{"label":"NCBI Gene 79444","url":"https://www.ncbi.nlm.nih.gov/gene/79444"},{"label":"Ensembl ENSG00000101197","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000101197"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Papillary Thyroid Carcinoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BIRC7","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:13702","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13702","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96CA5","url":"https://www.uniprot.org/uniprotkb/Q96CA5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene BIRC7","url":"https://civicdb.org/features/14842","note":"2 evidence items, 0 assertions, 1 variants; diseases: Colon Cancer, Papillary Thyroid Carcinoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA BIRC7: RNA tissue enhanced (placenta 6 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas BIRC7 tissue","url":"https://www.proteinatlas.org/ENSG00000101197-BIRC7/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000101197 associations","url":"https://platform.opentargets.org/target/ENSG00000101197/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:13702","ensembl":"ENSG00000101197","uniprot":"Q96CA5","entrez":"79444","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Lin J.-H. et al, Biochem. Biophys. Res. Commun, 2000, \"KIAP, a novel member of the inhibitor of apoptosis protein family\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/11162435/","biology":"Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. Location: Nucleus; Cytoplasm; Golgi apparatus (UniProt). Locus 20q13.33 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/birc7/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}