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ATF7IP (Activating transcription factor 7-interacting protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer and Non-small-cell lung cancer.
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.61, somatic mutation 0.54). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Lung Adenocarcinoma, Endometrial Carcinoma.
In plain words · ATF7IP (Activating transcription factor 7-interacting protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer and Non-small-cell lung cancer.
ATF7IP (Activating transcription factor 7-interacting protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer and Non-small-cell lung cancer.
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context.
No product in this corpus aims at ATF7IP yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2000. Earliest sequence paper UniProt cites for the protein: Gunther et al, Mol. Cell. Biochem, 2000, "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Source.
Sources: HGNC HGNC:20092 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6VMQ6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000171681 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0)); IntOGen ATF7IP (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilises SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Location: Nucleus (UniProt). Locus 12p13.1 (HGNC).
Query for this target: (TITLE:"ATF7IP" OR ABSTRACT:"ATF7IP" OR TITLE:"activating transcription factor 7 interacting protein" OR ABSTRACT:"activating transcription factor 7 interacting protein" OR TITLE:"Activating transcription factor 7-interacting protein 1" OR ABSTRACT:"Activating transcription factor 7-interacting protein 1" OR TITLE:"FLJ10688" OR ABSTRACT:"FLJ10688" OR TITLE:"p621" OR ABSTRACT:"p621" OR TITLE:"ATF7IP1" OR ABSTRACT:"ATF7IP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATF7IP, not a curated reading list.