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ATF7IP (Activating transcription factor 7-interacting protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer and Non-small-cell lung cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilises SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Location: Nucleus (UniProt). Locus 12p13.1 (HGNC).
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No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"ATF7IP" OR ABSTRACT:"ATF7IP" OR TITLE:"activating transcription factor 7 interacting protein" OR ABSTRACT:"activating transcription factor 7 interacting protein" OR TITLE:"Activating transcription factor 7-interacting protein 1" OR ABSTRACT:"Activating transcription factor 7-interacting protein 1" OR TITLE:"FLJ10688" OR ABSTRACT:"FLJ10688" OR TITLE:"p621" OR ABSTRACT:"p621" OR TITLE:"ATF7IP1" OR ABSTRACT:"ATF7IP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATF7IP, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/atf7ip.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/atf7ip.json. Licence CC BY-NC 4.0.