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ARHGEF10 (Rho guanine nucleotide exchange factor 10) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Cutaneous squamous cell carcinoma, Non-small-cell lung cancer and 1 more.
May play a role in developmental myelination of peripheral nerves.
IntOGen calls it a driver in 4 cohorts (1 activating, 3 loss-of-function), covering Bladder Urothelial Carcinoma, Cutaneous Squamous Cell Carcinoma, Non-Small Cell Lung Cancer, Small Cell Lung Cancer.
In plain words · ARHGEF10 (Rho guanine nucleotide exchange factor 10) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Cutaneous squamous cell carcinoma, Non-small-cell lung cancer and 1 more.
ARHGEF10 (Rho guanine nucleotide exchange factor 10) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Cutaneous squamous cell carcinoma, Non-small-cell lung cancer and 1 more.
May play a role in developmental myelination of peripheral nerves. Locus 8p23.3 (HGNC).
No product in this corpus aims at ARHGEF10 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1997. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1997, "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". Source.
Sources: HGNC HGNC:14103 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15013 (protein name, function text, keywords and locations (REST API)); IntOGen ARHGEF10 (driver in 4 cohorts (Act 1, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May play a role in developmental myelination of peripheral nerves. Locus 8p23.3 (HGNC).
Query for this target: (TITLE:"ARHGEF10" OR ABSTRACT:"ARHGEF10" OR TITLE:"Rho guanine nucleotide exchange factor 10" OR ABSTRACT:"Rho guanine nucleotide exchange factor 10" OR TITLE:"KIAA0294" OR ABSTRACT:"KIAA0294" OR TITLE:"Gef10" OR ABSTRACT:"Gef10") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ARHGEF10, not a curated reading list.
Shares Cutaneous squamous cell carcinoma, IntOGen.
Shares Cutaneous squamous cell carcinoma, Small-cell lung cancer, Non-small-cell lung cancer.
Shares Cutaneous squamous cell carcinoma, Non-small-cell lung cancer.
Shares Cutaneous squamous cell carcinoma, IntOGen.
Shares Cutaneous squamous cell carcinoma, Small-cell lung cancer, Non-small-cell lung cancer.
Shares Cutaneous squamous cell carcinoma, IntOGen.
Shares Cutaneous squamous cell carcinoma, Non-small-cell lung cancer.
Shares Cutaneous squamous cell carcinoma, Non-small-cell lung cancer.