{"entity":{"id":"arhgef10","kind":"target","name":"ARHGEF10","aka":["Rho guanine nucleotide exchange factor 10","KIAA0294","Gef10"],"tldr":"ARHGEF10 (Rho guanine nucleotide exchange factor 10) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Cutaneous squamous cell carcinoma, Non-small-cell lung cancer and 1 more.","summary":"May play a role in developmental myelination of peripheral nerves.\n\nIntOGen calls it a driver in 4 cohorts (1 activating, 3 loss-of-function), covering Bladder Urothelial Carcinoma, Cutaneous Squamous Cell Carcinoma, Non-Small Cell Lung Cancer, Small Cell Lung Cancer.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14103","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14103"},{"label":"UniProt O15013","url":"https://www.uniprot.org/uniprotkb/O15013/entry"},{"label":"NCBI Gene 9639","url":"https://www.ncbi.nlm.nih.gov/gene/9639"},{"label":"Ensembl ENSG00000104728","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104728"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["urothelial","cutaneous-scc","nsclc","sclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ARHGEF10","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:14103","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14103","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15013","url":"https://www.uniprot.org/uniprotkb/O15013/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ARHGEF10","url":"https://www.intogen.org/search?gene=ARHGEF10","note":"driver in 4 cohorts (Act 1, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:14103","ensembl":"ENSG00000104728","uniprot":"O15013","entrez":"9639","firstDescribed":1997,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1997, \"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9205841/","biology":"May play a role in developmental myelination of peripheral nerves. Locus 8p23.3 (HGNC).","whereFound":["Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Cutaneous squamous cell carcinoma: IntOGen driver in 1 cohort (CSCC)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (NSCLC)","Small-cell lung cancer: IntOGen driver in 1 cohort (SCLC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/arhgef10/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"cutaneous-scc","kind":"cancer","name":"Cutaneous squamous cell carcinoma","route":"/cancers/cutaneous-scc/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}]}}