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Targets ordered by how many cancers their record lists as places the target is found or acted on. Top 50 of 1,365 targets with a value; ties are broken by name. 1,365 of 1,674 targets list at least one cancer (82%).
| # | Target | Cancers | Prevalence rows |
|---|---|---|---|
| 1 | CDKN2A | 11 | 4 prevalence rows |
| 2 | MYC | 11 | 2 prevalence rows |
| 3 | RB1 | 11 | 3 prevalence rows |
| 4 | ARID1A | 10 | 3 prevalence rows |
| 5 | ATM | 10 | 3 prevalence rows |
| 6 | NOTCH1 | 10 | 2 prevalence rows |
| 7 | NRG1 | 10 | 2 prevalence rows |
| 8 | PALB2 | 10 | 4 prevalence rows |
| 9 | STK11 | 10 | 2 prevalence rows |
| 10 | TP53 | 10 | 14 prevalence rows |
| 11 | CCNE1 | 9 | 1 prevalence row |
| 12 | CDKN2B | 9 | 1 prevalence row |
| 13 | CTNNB1 | 9 | 2 prevalence rows |
| 14 | HER2 | 9 | 17 prevalence rows |
| 15 | MSH2 | 9 | 1 prevalence row |
| 16 | NFE2L2 | 9 | 1 prevalence row |
| 17 | PRKCB | 9 | 0 prevalence rows |
| 18 | SMAD4 | 9 | 3 prevalence rows |
| 19 | SMARCA4 | 9 | 1 prevalence row |
| 20 | AKAP9 | 8 | 0 prevalence rows |
| 21 | APC | 8 | 2 prevalence rows |
| 22 | ARHGAP35 | 8 | 0 prevalence rows |
| 23 | ARHGEF12 | 8 | 0 prevalence rows |
| 24 | ARID1B | 8 | 0 prevalence rows |
| 25 | ARID2 | 8 | 0 prevalence rows |
| 26 | ASXL1 | 8 | 0 prevalence rows |
| 27 | ATRX | 8 | 0 prevalence rows |
| 28 | AXIN1 | 8 | 0 prevalence rows |
| 29 | B2M | 8 | 1 prevalence row |
| 30 | BAP1 | 8 | 0 prevalence rows |
| 31 | BARD1 | 8 | 0 prevalence rows |
| 32 | BCL11B | 8 | 0 prevalence rows |
| 33 | BCOR | 8 | 0 prevalence rows |
| 34 | BIRC6 | 8 | 0 prevalence rows |
| 35 | CACNA1D | 8 | 0 prevalence rows |
| 36 | CARD11 | 8 | 0 prevalence rows |
| 37 | CASP8 | 8 | 0 prevalence rows |
| 38 | CBL | 8 | 0 prevalence rows |
| 39 | CCND1 | 8 | 0 prevalence rows |
| 40 | CD3D | 8 | 0 prevalence rows |
| 41 | CD3G | 8 | 0 prevalence rows |
| 42 | CD44 | 8 | 0 prevalence rows |
| 43 | CDH1 | 8 | 0 prevalence rows |
| 44 | CDH11 | 8 | 0 prevalence rows |
| 45 | CDK12 | 8 | 1 prevalence row |
| 46 | CDKN1B | 8 | 1 prevalence row |
| 47 | CHD2 | 8 | 0 prevalence rows |
| 48 | CHD4 | 8 | 0 prevalence rows |
| 49 | CHEK2 | 8 | 0 prevalence rows |
| 50 | CLTC | 8 | 0 prevalence rows |
1,315 more targets have a value below the top 50; the full list of targets is at /targets/.
Counts entries in each target's cancers field. The context column counts the target's sourced prevalence rows (a percentage of a cancer carrying the alteration).
Coverage. 1,365 of 1,674 targets list at least one cancer (82%). Rows with a value of zero are not listed. Nothing is weighted, imputed or averaged; the ordering is by the number shown, then by name.
Machine-readable copy: /rankings/targets-by-cancers/data.json. Registry: src/lib/rankings.ts.