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Cloned the T-cell receptor and co-discovered CTLA-4's brake function, foundations of modern immunotherapy.
Tak W. Mak is a Senior Scientist at the Princess Margaret Cancer Centre and University Professor at the University of Toronto. He is an immunologist known for cloning the human T-cell receptor beta chain in 1984 and for generating the CTLA-4 knockout mouse that revealed the molecule's inhibitory role, foundations of modern immunotherapy. His selected paper reports lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. He now studies cancer metabolism and IDH mutations alongside his continuing interest in immune checkpoints.
| Title | Journal | Year |
|---|---|---|
| Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4 | Science | 1995 |
Shares Princess Margaret Cancer Centre, Immune checkpoint inhibitors.
Shares CTLA-4, Immune checkpoint inhibitors.
Shares CTLA-4, Immune checkpoint inhibitors.
Shares CTLA-4, Immune checkpoint inhibitors.
Shares CTLA-4, Immune checkpoint inhibitors.
Shares CTLA-4, Immune checkpoint inhibitors.
Shares CTLA-4, Immune checkpoint inhibitors.
Shares CTLA-4, Immune checkpoint inhibitors.