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Paris surgeon who championed compartmental resection for retroperitoneal sarcoma and led STRASS, the trial that showed preoperative radiotherapy does not improve abdominal recurrence-free survival overall.
Sylvie Bonvalot is a sarcoma surgeon at Institut Curie in Paris. She was first author of the 2009 Journal of Clinical Oncology study showing that systematic en bloc resection of adjacent organs reduced local recurrence in primary retroperitoneal sarcoma, and of the 2020 Lancet Oncology report of the EORTC STRASS trial, in which preoperative radiotherapy did not significantly improve abdominal recurrence-free survival compared with surgery alone, though a possible benefit in liposarcoma remains under study.
| Title | Journal | Year |
|---|---|---|
| Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control | Journal of Clinical Oncology | 2009 |
| STRASS (EORTC 62092): preoperative radiotherapy plus surgery versus surgery alone for primary retroperitoneal sarcoma | The Lancet Oncology | 2020 |
Surgery alone in a reference centre is the standard for primary retroperitoneal sarcoma; preoperative radiotherapy is considered case by case in liposarcoma.
This trial validated the radioenhancer mode of action and supported the 2019 European CE mark for NBTXR3 (Hensify) in soft-tissue sarcoma. Whether more pathological complete responses translate into fewer recurrences or longer survival was not shown here; the 2022 follow-up paper reported more R0 resections and no harm to quality of life.
Extended en bloc resection in a sarcoma reference centre is the standard operation for retroperitoneal sarcoma.
Shares Retroperitoneal sarcoma, Sarcomas (soft tissue, bone, GIST) and the tags sarcoma, trialist.
Shares Liposarcoma, Sarcomas (soft tissue, bone, GIST) and the tags sarcoma, trialist.
Shares Sarcomas (soft tissue, bone, GIST) and the tags sarcoma, surgery, trialist.
Shares Sarcomas (soft tissue, bone, GIST) and the tags sarcoma, trialist.
Shares Sarcomas (soft tissue, bone, GIST) and the tags sarcoma, trialist.
Shares Sarcomas (soft tissue, bone, GIST) and the tags sarcoma, trialist.
Shares STRASS (EORTC 62092): preoperative radiotherapy plus surgery versus surgery alone for primary retroperitoneal sarcoma, Retroperitoneal sarcoma, Liposarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Sarcomas (soft tissue, bone, GIST) and the tags sarcoma, trialist.