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This French multicentre study showed that resecting a retroperitoneal sarcoma together with the adjacent organs, even when not obviously involved, reduced local recurrence more than threefold, establishing the compartmental surgical approach.
Retrospective analysis of 382 patients with primary retroperitoneal sarcoma from French Sarcoma Group centres examining surgical technique, margins and outcomes.
Systematic en bloc resection of adjacent organs (compartmental resection) was associated with a 3.29-fold lower risk of abdominal recurrence compared with simple complete resection, without higher mortality, while incomplete resection and high grade predicted recurrence.
Extended en bloc resection in a sarcoma reference centre is the standard operation for retroperitoneal sarcoma.