{"entity":{"id":"sylvie-bonvalot","kind":"person","name":"Sylvie Bonvalot","aka":[],"tldr":"Paris surgeon who championed compartmental resection for retroperitoneal sarcoma and led STRASS, the trial that showed preoperative radiotherapy does not improve abdominal recurrence-free survival overall.","summary":"Sylvie Bonvalot is a sarcoma surgeon at Institut Curie in Paris. She was first author of the 2009 Journal of Clinical Oncology study showing that systematic en bloc resection of adjacent organs reduced local recurrence in primary retroperitoneal sarcoma, and of the 2020 Lancet Oncology report of the EORTC STRASS trial, in which preoperative radiotherapy did not significantly improve abdominal recurrence-free survival compared with surgery alone, though a possible benefit in liposarcoma remains under study.","asOf":"2026-09-18","links":[],"tags":["sarcoma","surgery","trialist"],"related":[],"cancers":["retroperitoneal-sarcoma","liposarcoma","sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["institut-curie"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-strass-lancet-oncol-2020","paper-bonvalot-retroperitoneal-sarcoma-compartmental-jco-2009"],"journals":[],"dependsOn":[],"notes":[],"role":"Surgical oncologist, Institut Curie, Paris","institutionId":"institut-curie","specialisms":["Retroperitoneal sarcoma","Sarcoma surgery","Preoperative radiotherapy"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Bonvalot%5BAuthor%5D"}],"papers":[{"title":"Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control","journal":"Journal of Clinical Oncology","year":2009,"url":"https://doi.org/10.1200/JCO.2008.18.0802","doi":"10.1200/JCO.2008.18.0802"},{"title":"STRASS (EORTC 62092): preoperative radiotherapy plus surgery versus surgery alone for primary retroperitoneal sarcoma","journal":"The Lancet Oncology","year":2020,"url":"https://doi.org/10.1016/S1470-2045(20)30446-0","doi":"10.1016/S1470-2045(20)30446-0"}]},"route":"/people/sylvie-bonvalot/","neighbours":{"cancer":[{"id":"liposarcoma","kind":"cancer","name":"Liposarcoma","route":"/cancers/liposarcoma/"},{"id":"retroperitoneal-sarcoma","kind":"cancer","name":"Retroperitoneal sarcoma","route":"/cancers/retroperitoneal-sarcoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}],"institution":[{"id":"institut-curie","kind":"institution","name":"Institut Curie","route":"/institutions/institut-curie/"}],"paper":[{"id":"paper-act-in-sarc-lancet-oncol-2019","kind":"paper","name":"NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): a multicentre, phase 2-3, randomised, controlled trial","route":"/key-papers/paper-act-in-sarc-lancet-oncol-2019/"},{"id":"paper-bonvalot-retroperitoneal-sarcoma-compartmental-jco-2009","kind":"paper","name":"Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control","route":"/key-papers/paper-bonvalot-retroperitoneal-sarcoma-compartmental-jco-2009/"},{"id":"paper-strass-lancet-oncol-2020","kind":"paper","name":"STRASS (EORTC 62092): preoperative radiotherapy plus surgery versus surgery alone for primary retroperitoneal sarcoma","route":"/key-papers/paper-strass-lancet-oncol-2020/"}],"trial":[{"id":"act-in-sarc","kind":"trial","name":"Act.In.Sarc","route":"/trials/act-in-sarc/"}]}}