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Paris paediatric neuro-oncologist who led HERBY, the trial that showed adding bevacizumab does not help children with high-grade glioma, and who leads European trials in diffuse midline glioma.
Jacques Grill leads paediatric neuro-oncology at Gustave Roussy and the BIOMEDE programme of biology-driven trials for diffuse intrinsic pontine glioma. He was first author of the 2018 Journal of Clinical Oncology report of HERBY, the randomised trial in which bevacizumab added to radiotherapy and temozolomide did not improve event-free survival in children with newly diagnosed non-brainstem high-grade glioma. He chairs the SIOP Europe high-grade glioma group.
| Title | Journal | Year |
|---|---|---|
| Integrated molecular meta-analysis of 1,000 paediatric high-grade and diffuse intrinsic pontine gliomas Europe PMC author record matched by affiliation (Gustave Roussy); 974 citations on Europe PMC. | Cancer Cell | 2017 |
| New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs Europe PMC author record matched by affiliation (Gustave Roussy); 730 citations on Europe PMC. | Cell | 2016 |
| Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes Europe PMC author record matched by affiliation (Gustave Roussy); 477 citations on Europe PMC. | Acta neuropathologica | 2015 |
The 2021 WHO paediatric-type diffuse high-grade glioma categories, and the practice of profiling every childhood glioma for a targetable fusion or mutation, rest on this landscape.
One of the most cited papers Europe PMC returns for Jacques Grill at Gustave Roussy, so it is a natural starting point for reading their work. The record was linked automatically from the author list and affiliation; read the abstract above and the paper itself before relying on any figure.
One of the most cited papers Europe PMC returns for Jacques Grill at Gustave Roussy, so it is a natural starting point for reading their work. The record was linked automatically from the author list and affiliation; read the abstract above and the paper itself before relying on any figure.
Shares Childhood cancers (all types) and the tags paediatric, brain, trialist.
Shares Paediatric high-grade glioma (excluding diffuse midline glioma), Childhood cancers (all types) and the tags paediatric, brain, trialist.
Shares Childhood cancers (all types) and the tags paediatric, brain, trialist.
Shares Glioma & glioblastoma and the tags brain, trialist.
Shares Glioma & glioblastoma and the tags brain, trialist.
Shares the tags brain, trialist.
Shares Childhood cancers (all types) and the tags paediatric, trialist.
Shares Childhood cancers (all types) and the tags paediatric, trialist.