# Jacques Grill

Source: https://onco.cc/people/jacques-grill/  
OnCo record `jacques-grill` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paris paediatric neuro-oncologist who led HERBY, the trial that showed adding bevacizumab does not help children with high-grade glioma, and who leads European trials in diffuse midline glioma.

## Summary

Jacques Grill leads paediatric neuro-oncology at Gustave Roussy and the BIOMEDE programme of biology-driven trials for diffuse intrinsic pontine glioma. He was first author of the 2018 Journal of Clinical Oncology report of HERBY, the randomised trial in which bevacizumab added to radiotherapy and temozolomide did not improve event-free survival in children with newly diagnosed non-brainstem high-grade glioma. He chairs the SIOP Europe high-grade glioma group.

## Fields

- Kind: Person
- Last checked: 2026-09-18
- Tags: paediatric; brain; trialist
- Role: Paediatric neuro-oncologist, Gustave Roussy
- Specialisms: Paediatric high-grade glioma; Diffuse midline glioma; Paediatric brain tumour trials

## Connected records

- cancers: [Childhood cancers (all types)](https://onco.cc/cancers/childhood-cancers/), [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/), [Paediatric high-grade glioma (excluding diffuse midline glioma)](https://onco.cc/cancers/paediatric-high-grade-glioma/)
- institutions: [Gustave Roussy](https://onco.cc/institutions/gustave-roussy/)
- trials: [HERBY](https://onco.cc/trials/herby/)
- key papers: [Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes](https://onco.cc/key-papers/paper-jacques-grill-acta-neuropathol-2015/), [Integrated molecular meta-analysis of 1,000 paediatric high-grade and diffuse intrinsic pontine gliomas](https://onco.cc/key-papers/paper-mackay-paediatric-hgg-cancer-cell-2017/), [New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs](https://onco.cc/key-papers/paper-jacques-grill-cell-2016/)

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