{"entity":{"id":"jacques-grill","kind":"person","name":"Jacques Grill","aka":[],"tldr":"Paris paediatric neuro-oncologist who led HERBY, the trial that showed adding bevacizumab does not help children with high-grade glioma, and who leads European trials in diffuse midline glioma.","summary":"Jacques Grill leads paediatric neuro-oncology at Gustave Roussy and the BIOMEDE programme of biology-driven trials for diffuse intrinsic pontine glioma. He was first author of the 2018 Journal of Clinical Oncology report of HERBY, the randomised trial in which bevacizumab added to radiotherapy and temozolomide did not improve event-free survival in children with newly diagnosed non-brainstem high-grade glioma. He chairs the SIOP Europe high-grade glioma group.","asOf":"2026-09-18","links":[],"tags":["paediatric","brain","trialist"],"related":[],"cancers":["paediatric-high-grade-glioma","glioblastoma","childhood-cancers"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["gustave-roussy"],"pathways":[],"terms":[],"trials":["herby"],"people":[],"bottlenecks":[],"keyPapers":["paper-mackay-paediatric-hgg-cancer-cell-2017","paper-jacques-grill-cell-2016","paper-jacques-grill-acta-neuropathol-2015"],"journals":[],"dependsOn":[],"notes":[],"role":"Paediatric neuro-oncologist, Gustave Roussy","institutionId":"gustave-roussy","specialisms":["Paediatric high-grade glioma","Diffuse midline glioma","Paediatric brain tumour trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Grill%5BAuthor%5D"}],"papers":[{"title":"Integrated molecular meta-analysis of 1,000 paediatric high-grade and diffuse intrinsic pontine gliomas","journal":"Cancer Cell","year":2017,"url":"https://doi.org/10.1016/j.ccell.2017.08.017","doi":"10.1016/j.ccell.2017.08.017","note":"Europe PMC author record matched by affiliation (Gustave Roussy); 974 citations on Europe PMC."},{"title":"New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs","journal":"Cell","year":2016,"url":"https://doi.org/10.1016/j.cell.2016.01.015","doi":"10.1016/j.cell.2016.01.015","note":"Europe PMC author record matched by affiliation (Gustave Roussy); 730 citations on Europe PMC."},{"title":"Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes","journal":"Acta neuropathologica","year":2015,"url":"https://doi.org/10.1007/s00401-015-1478-0","doi":"10.1007/s00401-015-1478-0","note":"Europe PMC author record matched by affiliation (Gustave Roussy); 477 citations on Europe PMC."}],"orcid":"0000-0003-4773-3001"},"route":"/people/jacques-grill/","neighbours":{"cancer":[{"id":"childhood-cancers","kind":"cancer","name":"Childhood cancers (all types)","route":"/cancers/childhood-cancers/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"paediatric-high-grade-glioma","kind":"cancer","name":"Paediatric high-grade glioma (excluding diffuse midline glioma)","route":"/cancers/paediatric-high-grade-glioma/"}],"institution":[{"id":"gustave-roussy","kind":"institution","name":"Gustave Roussy","route":"/institutions/gustave-roussy/"}],"trial":[{"id":"herby","kind":"trial","name":"HERBY","route":"/trials/herby/"}],"paper":[{"id":"paper-jacques-grill-acta-neuropathol-2015","kind":"paper","name":"Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes","route":"/key-papers/paper-jacques-grill-acta-neuropathol-2015/"},{"id":"paper-mackay-paediatric-hgg-cancer-cell-2017","kind":"paper","name":"Integrated molecular meta-analysis of 1,000 paediatric high-grade and diffuse intrinsic pontine gliomas","route":"/key-papers/paper-mackay-paediatric-hgg-cancer-cell-2017/"},{"id":"paper-jacques-grill-cell-2016","kind":"paper","name":"New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs","route":"/key-papers/paper-jacques-grill-cell-2016/"}]}}