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Led the NELSON trial, which confirmed CT screening cuts lung cancer deaths in Europe and shaped screening policy.
Harry de Koning was principal investigator of NELSON, the Dutch-Belgian randomised trial showing low-dose CT screening reduces lung cancer mortality by about a quarter in high-risk men, the result that pushed European countries toward screening programmes. His MISCAN microsimulation models underpin US and European screening guidelines for lung, breast, prostate and colorectal cancer.
| Title | Journal | Year |
|---|---|---|
| Reduced lung-cancer mortality with volume CT screening in a randomized trial (NELSON) | NEJM | 2020 |
| Benefits and harms of computed tomography lung cancer screening strategies: a comparative modeling study for the U.S. Preventive Services Task Force | Annals of Internal Medicine | 2014 |
| NLST: yearly low-dose CT scans cut lung cancer deaths in heavy smokers | New England Journal of Medicine | 2011 |
Lung screening works when it uses volumetric nodule management, and it works against a no-screening control. The protocol underpins the UK Targeted Lung Health Check programme and European recommendations. Benefit in women remains less precisely estimated.
For people with a heavy smoking history, an annual low-dose CT scan is one of the few screening tests proven to reduce cancer deaths. Most abnormal scans are not cancer, so screening must be paired with careful nodule management. It does not apply to never-smokers or light smokers.
Shares NLST & NELSON (low-dose CT screening), NLST: yearly low-dose CT scans cut lung cancer deaths in heavy smokers, CT (computed tomography), Non-small-cell lung cancer and the tags screening, lung.
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