{"entity":{"id":"harry-de-koning","kind":"person","name":"Harry J. de Koning","aka":[],"tldr":"Led the NELSON trial, which confirmed CT screening cuts lung cancer deaths in Europe and shaped screening policy.","summary":"Harry de Koning was principal investigator of NELSON, the Dutch-Belgian randomised trial showing low-dose CT screening reduces lung cancer mortality by about a quarter in high-risk men, the result that pushed European countries toward screening programmes. His MISCAN microsimulation models underpin US and European screening guidelines for lung, breast, prostate and colorectal cancer.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=de%20Koning%20HJ%5BAuthor%5D%20screening"}],"tags":["screening","lung","epidemiology"],"related":[],"cancers":["nsclc","prostate"],"sections":[],"technologies":["ct"],"targets":[],"drugs":[],"companies":[],"institutions":["erasmus-mc"],"pathways":[],"terms":[],"trials":["nlst-nelson"],"people":[],"bottlenecks":[],"keyPapers":["paper-nelson-nejm-2020","paper-nlst-nejm-2011"],"journals":["annals-internal-medicine"],"dependsOn":[],"notes":[],"role":"Professor of Public Health and Screening Evaluation, Erasmus MC","institutionId":"erasmus-mc","specialisms":["Cancer screening evaluation","Lung cancer CT screening","Microsimulation modelling","Prostate and breast screening"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=de%20Koning%20HJ%5BAuthor%5D%20screening"}],"papers":[{"title":"Reduced lung-cancer mortality with volume CT screening in a randomized trial (NELSON)","journal":"NEJM","year":2020,"doi":"10.1056/NEJMoa1911793"},{"title":"Benefits and harms of computed tomography lung cancer screening strategies: a comparative modeling study for the U.S. Preventive Services Task Force","journal":"Annals of Internal Medicine","year":2014,"doi":"10.7326/M13-2316"},{"title":"NLST: yearly low-dose CT scans cut lung cancer deaths in heavy smokers","journal":"New England Journal of Medicine","year":2011,"url":"https://doi.org/10.1056/NEJMoa1102873","doi":"10.1056/NEJMoa1102873"}],"orcid":"0000-0003-4682-3646"},"route":"/people/harry-de-koning/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"ct","kind":"technology","name":"CT (computed tomography)","route":"/technologies/ct/"}],"institution":[{"id":"erasmus-mc","kind":"institution","name":"Erasmus MC Cancer Institute","route":"/institutions/erasmus-mc/"}],"trial":[{"id":"nlst-nelson","kind":"trial","name":"NLST & NELSON (low-dose CT screening)","route":"/trials/nlst-nelson/"}],"paper":[{"id":"paper-nelson-nejm-2020","kind":"paper","name":"NELSON: volume-based CT screening reduces lung cancer deaths with fewer false alarms","route":"/key-papers/paper-nelson-nejm-2020/"},{"id":"paper-nlst-nejm-2011","kind":"paper","name":"NLST: yearly low-dose CT scans cut lung cancer deaths in heavy smokers","route":"/key-papers/paper-nlst-nejm-2011/"}],"journal":[{"id":"annals-internal-medicine","kind":"journal","name":"Annals of Internal Medicine","route":"/journals/annals-internal-medicine/"}]}}