Loading
Comparing the ages of Chilean patients with dysplasia, early cancer, advanced cancer and spread cancer of the gallbladder, the authors estimated that it takes around 15 years to go from dysplasia to advanced disease.
84 cases of dysplasia, 60 early carcinomas, 181 advanced carcinomas and 121 metastatic gallbladder cancers were analysed using age as the main parameter, with analysis of variance and multiple regression. Women were younger than men across all lesions, and mean age differed by lesion type: 46.3 years (SD 16) for dysplasia, 57.5 (16.7) for early carcinoma, 59 (13.7) for advanced carcinoma and 61.1 (12.1) for metastatic disease.
Multiple regression showed a significant difference in mean age between dysplastic and carcinoma groups (r = 0.386; P < 0.001). The period required to progress from dysplasia to advanced carcinoma was estimated at around 15 years, with a continuum in the progression of the lesions.
The origin of the 10 to 15 year window quoted for gallbladder carcinogenesis, which is the argument that cholecystectomy for stones or dysplasia in high-incidence regions prevents cancer years later.
Shares Metaplasia, dysplasia, carcinoma in situ: the flat route to gallbladder cancer, Dysplasia (pre-cancerous change), Gallbladder cancer.
Shares Metaplasia, dysplasia, carcinoma in situ: the flat route to gallbladder cancer, Dysplasia (pre-cancerous change), Gallbladder cancer.
Shares Metaplasia, dysplasia, carcinoma in situ: the flat route to gallbladder cancer, Dysplasia (pre-cancerous change), Gallbladder cancer.
Shares Dysplasia (pre-cancerous change), Gallbladder cancer.
Shares Dysplasia (pre-cancerous change), Gallbladder cancer.
Shares Metaplasia, dysplasia, carcinoma in situ: the flat route to gallbladder cancer, Gallbladder cancer.
Shares Dysplasia (pre-cancerous change), Gallbladder cancer.