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The ProMisE classifier uses three tests, mismatch repair and p53 immunohistochemistry plus POLE sequencing, to sort endometrial cancers into four molecular groups that reproduce the Cancer Genome Atlas subtypes and predict outcome.
Confirmation study in 319 endometrial cancers of the Proactive Molecular Risk Classifier for Endometrial Cancer, assigning tumours to POLE-mutated, mismatch repair-deficient, p53-abnormal or p53 wild-type (no specific molecular profile) groups using immunohistochemistry and targeted sequencing.
The classifier was reproducible, could be applied to biopsy material and stratified survival, with POLE tumours faring best and p53-abnormal worst, independent of traditional risk factors.
Molecular classification of every endometrial cancer, now embedded in the WHO classification and the ESGO/ESTRO/ESP guideline, rests on ProMisE; it decides adjuvant therapy and identifies candidates for immunotherapy.
Shares POLE-ultramutated endometrial cancer, p53-abnormal endometrial cancer, including uterine serous carcinoma, Mismatch-repair-deficient endometrial cancer.
Shares POLE-ultramutated endometrial cancer, p53-abnormal endometrial cancer, including uterine serous carcinoma.
Shares POLE-ultramutated endometrial cancer, Endometrial cancer with no specific molecular profile.
Shares POLE-ultramutated endometrial cancer, p53-abnormal endometrial cancer, including uterine serous carcinoma, Endometrial cancer with no specific molecular profile, Mismatch-repair-deficient endometrial cancer.
Shares Endometrial cancer with no specific molecular profile, Mismatch-repair-deficient endometrial cancer.
Shares POLE-ultramutated endometrial cancer, p53-abnormal endometrial cancer, including uterine serous carcinoma, Endometrial cancer with no specific molecular profile, Mismatch-repair-deficient endometrial cancer.
Shares POLE-ultramutated endometrial cancer, Endometrial cancer with no specific molecular profile.
Shares POLE-ultramutated endometrial cancer, Endometrial cancer with no specific molecular profile.