Loading
The number used to convert proton gray into X-ray gray (1.1) is a convention. The true relative effect is higher where the beam stops, and it depends on the tissue and the size of each dose.
Paganetti reviewed laboratory and clinical estimates of proton relative biological effectiveness and showed systematic variation with linear energy transfer, dose per fraction, and biological endpoint. The distal edge is the region of concern. The paper is why variable-RBE planning exists and why constant 1.1 remains a reporting rule rather than a measurement.
A proton plan that looks safe on a 1.1 RBE map can still over-dose a late-responding organ sitting on the distal edge. Comparing protons with IMRT without an LET-weighted view asks the wrong physical question.
Shares Bragg peak, Relative biological effectiveness (RBE), Linear energy transfer (LET), Use LET, RBE and alpha/beta to decide when protons beat IMRT and the tag radiation-wave5.
Shares Bragg peak, Pencil-beam scanning and intensity-modulated proton therapy, Alpha/beta ratio, Relative biological effectiveness (RBE) and the tag radiation-wave5.
Shares Bragg peak, Alpha/beta ratio, Relative biological effectiveness (RBE), Linear energy transfer (LET) and the tag radiation-wave5.
Shares Bragg peak, Relative biological effectiveness (RBE), Linear energy transfer (LET), Proton therapy and the tag radiation-wave5.
Shares Relative biological effectiveness (RBE), Linear energy transfer (LET).
Shares Alpha/beta ratio, Relative biological effectiveness (RBE), Linear energy transfer (LET), Use LET, RBE and alpha/beta to decide when protons beat IMRT.
Shares Bragg peak, Pencil-beam scanning and intensity-modulated proton therapy, Proton therapy.
Shares Relative biological effectiveness (RBE), Use LET, RBE and alpha/beta to decide when protons beat IMRT, Proton therapy.