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Across 17 studies, mostly from India and China, people who carried the typhoid bacterium long term were about four times as likely to have gallbladder cancer, and the authors suggest offering them gallbladder removal or ultrasound checks.
Systematic review of MEDLINE, PubMed, EMBASE, Cochrane and other databases identifying 17 studies of chronic Salmonella Typhi carriage and gallbladder carcinoma. The pooled odds ratio for chronic carrier state was 4.28 (95 percent CI 1.84 to 9.96); most studies were from South Asia, especially India and China, and the South-East Asian subgroup odds ratio was 4.13 (2.87 to 5.94). The authors conclude chronic carriage is an important risk factor and that management should include elective cholecystectomy or careful ultrasound monitoring.
No trial has tested cholecystectomy or surveillance for chronic carriers; the recommendation is expert inference from a fourfold risk. It is one of the prevention ideas on this page.
Shares Prophylactic (preventive) cholecystectomy, Screening, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Prevention we already have is not deployed and the tag gallbladder-evidence.
Shares Prophylactic (preventive) cholecystectomy, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Prevention we already have is not deployed, Gallbladder cancer and the tag gallbladder-evidence.
Shares Prophylactic (preventive) cholecystectomy, Screening, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Prevention we already have is not deployed and the tag gallbladder-evidence.
Shares Prophylactic (preventive) cholecystectomy, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares Screening, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares Screening, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares Prophylactic (preventive) cholecystectomy, Gallbladder cancer and the tag gallbladder-evidence.
Shares Prophylactic (preventive) cholecystectomy, Screening, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.