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Removing only the first draining lymph node in the groin, and leaving the rest when it was clear, was safe for women with small vulvar cancers: very few groins relapsed and the swelling and wound problems of full groin surgery were largely avoided.
Prospective multicentre observational study of 403 women with unifocal vulvar squamous cell carcinoma under 4 cm and clinically negative groins who had sentinel node detection with radiotracer and blue dye; inguinofemoral lymphadenectomy was omitted when the sentinel node was negative.
Groin recurrence occurred in 2.3 percent of women with a negative sentinel node, three-year survival was 97 percent, and wound breakdown, infection and lymphoedema were far less common than after full lymphadenectomy. The procedure became the standard for early vulvar cancer.
Women with small, unifocal vulvar cancers and clinically negative groins can be staged with a sentinel node procedure and spared full groin dissection when the node is clear.
Shares HPV-independent vulvar squamous cell carcinoma (p53-mutant), HPV-associated vulvar squamous cell carcinoma, Journal of Clinical Oncology.
Shares HPV-independent vulvar squamous cell carcinoma (p53-mutant), HPV-associated vulvar squamous cell carcinoma.
Shares HPV-independent vulvar squamous cell carcinoma (p53-mutant), HPV-associated vulvar squamous cell carcinoma.
Shares HPV-independent vulvar squamous cell carcinoma (p53-mutant), HPV-associated vulvar squamous cell carcinoma.
Shares HPV-independent vulvar squamous cell carcinoma (p53-mutant), HPV-associated vulvar squamous cell carcinoma.
Shares HPV-independent vulvar squamous cell carcinoma (p53-mutant), HPV-associated vulvar squamous cell carcinoma.
Shares HPV-independent vulvar squamous cell carcinoma (p53-mutant), HPV-associated vulvar squamous cell carcinoma.
Shares HPV-independent vulvar squamous cell carcinoma (p53-mutant), HPV-associated vulvar squamous cell carcinoma.