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Offer a large cash prize to whoever proves, in a rigorous trial, that a cheap existing drug helps people with cancer live longer. Prizes pull effort towards neglected problems.
Inducement prizes (the Longitude Prize, XPRIZE, the Antibiotic Longitude Prize) attract effort where markets do not. For repurposing, the payoff to society is large but no single actor can capture it. The proposal is a prize, funded by philanthropy and payers, awarded to the sponsor of the first adequately powered randomised trial showing a pre-specified overall survival improvement with an off-patent drug in a defined cancer setting, with smaller prizes for definitive negative results that close a widely used off-label practice.
Shares The Repurposing Drugs in Oncology (ReDO) Project, No incentive to repurpose cheap drugs, Incentives reward me-too drugs and marginal gains.
Shares The Repurposing Drugs in Oncology (ReDO) Project, No incentive to repurpose cheap drugs, Incentives reward me-too drugs and marginal gains.
Shares The Repurposing Drugs in Oncology (ReDO) Project, No incentive to repurpose cheap drugs.
Shares The Repurposing Drugs in Oncology (ReDO) Project, No incentive to repurpose cheap drugs.
Shares The Repurposing Drugs in Oncology (ReDO) Project, No incentive to repurpose cheap drugs.
Shares The Repurposing Drugs in Oncology (ReDO) Project, No incentive to repurpose cheap drugs.
Shares The Repurposing Drugs in Oncology (ReDO) Project, No incentive to repurpose cheap drugs, Incentives reward me-too drugs and marginal gains.
Shares The Repurposing Drugs in Oncology (ReDO) Project, No incentive to repurpose cheap drugs.