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Precancer is treated by cutting away part of the cervix, which raises pregnancy risks. A vaccine that makes the immune system clear the infected cells would avoid surgery.
Cervical precancer is treated by cutting away part of the cervix, which raises pregnancy risks, so this idea develops next-generation therapeutic vaccines, mRNA or E6/E7-targeted, that make the immune system clear CIN2/3 lesions, aimed first at women planning pregnancy. HPV oncoproteins are foreign antigens present in every lesion cell, and DNA vaccines such as VGX-3100 have already shown partial efficacy. Endpoints would be histological regression and HPV clearance at six months, allowing surgery to be avoided. The test is a phase 2b RCT of 400 women with a regression endpoint. At early-clinical maturity it addresses the bottlenecks Prevention we already have is not deployed and Overdiagnosis and false alarms, and relates to Cancer interception vaccines for high-risk carriers.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed, Cervical cancer.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, HPV & HBV vaccination, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed.