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Women who never book a smear test are missed by invitation-based screening. Posting an HPV self-sampling kit as the default invitation, as the Netherlands and Australia do, reaches them, and PCR-based self-samples match clinician samples for detecting high-grade precancer.
HPV self-sampling has equivalent sensitivity to clinician-collected samples for CIN2+ with PCR-based tests. Propose opt-out mailed kits as the default invitation for all eligible women, with clinician sampling as an alternative, and triage of positives by extended genotyping or methylation to avoid unnecessary colposcopy.
One bottleneck page and 27 idea pages on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
Women can collect their own screening sample at home with no loss of accuracy if the laboratory uses a PCR test. Sending kits directly is the most effective way to reach women who do not attend, which matters because most cervical cancers occur in under-screened women.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Prevention we already have is not deployed.
Shares Self-collected HPV samples are as accurate as clinician samples and reach women who never attend screening, Prevention we already have is not deployed, Cervical cancer.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed, Cervical cancer.