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Oesophagectomy is one of the hardest operations in surgery. If chemoradiation (with or without immunotherapy) has made the tumour disappear, skip it and watch.
SANO showed non-inferior 2-year survival for active surveillance in clinical complete responders after CROSS. Adding PD-1 blockade to chemoradiation (KEYNOTE-975, SKYSCRAPER-07, ESCORT-CRT) may raise complete response rates and make surveillance viable for more patients; ctDNA and PET could sharpen response assessment.
Shares SANO, Clinical complete response (cCR), CROSS, Oesophageal cancer.
Shares SANO, CROSS, Oesophageal cancer.
Shares SANO, CROSS, Oesophageal cancer.
Shares CROSS, Oesophageal cancer.
Shares Surgery and radiotherapy cure most, get least, IMRT / IGRT (modern external beam).
Shares Surgery and radiotherapy cure most, get least, IMRT / IGRT (modern external beam).
Shares CROSS, Oesophageal cancer, Immune checkpoint inhibitors.
Shares CROSS, Oesophageal cancer.