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Half of patients take antioxidant vitamins during chemotherapy. One good observational study suggests they raise recurrence by 40%. Patients deserve a definitive answer, and it can be obtained cheaply by adding supplement tracking to trials already running.
The DELCaP study nested in a breast cancer chemotherapy trial found that antioxidant supplements (vitamins A, C, E, carotenoids, coenzyme Q10) taken before and during chemotherapy were associated with a 41% higher recurrence and 40% higher mortality, with similar signals for vitamin B12, iron and omega-3. Randomised harm has been shown for beta-carotene in smokers and for antioxidants during head and neck radiotherapy. A randomised trial of antioxidants during chemotherapy is now ethically difficult; the pragmatic path is prospective supplement capture in every adjuvant trial and a pre-registered pooled analysis, plus a randomised trial of a stop-supplement counselling intervention.
Shares Cancer Misinformation and Harmful Information on Facebook and Other Social Media: A Brief Report, Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Oncology nutrition assessment and medical nutrition therapy, Dietary supplements during cancer treatment: interactions and harms.
Shares An open supplement-drug interaction checker built into oncology prescribing, Dietary supplements during cancer treatment: interactions and harms, Misinformation and unproven therapies, Memorial Sloan Kettering Cancer Center.
Shares Cancer Misinformation and Harmful Information on Facebook and Other Social Media: A Brief Report, Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Misinformation and unproven therapies.
Shares Cancer Misinformation and Harmful Information on Facebook and Other Social Media: A Brief Report, Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Oncology nutrition assessment and medical nutrition therapy, Misinformation and unproven therapies.
Shares Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Dietary supplements during cancer treatment: interactions and harms, Misinformation and unproven therapies.
Shares Misinformation and unproven therapies, Triple-negative breast cancer (TNBC), HR-positive / HER2-negative breast cancer, Colorectal cancer.
Shares Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Dietary supplements during cancer treatment: interactions and harms, Misinformation and unproven therapies, HR-positive / HER2-negative breast cancer.
Shares Cancer Misinformation and Harmful Information on Facebook and Other Social Media: A Brief Report, Misinformation and unproven therapies, Toxicity and quality of life are undervalued.