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Academic labs find new tumour targets but cannot turn an antibody into an antibody-drug conjugate or a bispecific without licensed linker and payload technology. A shared platform would provide that at no cost for first trials.
A publicly-funded platform holding licences (or developing its own patent-free versions) for linker-payload chemistries, site-specific conjugation, bispecific formats and CAR constructs, offered royalty-free to academic teams for research and first-in-human studies, with commercial terms triggered only on licensing to a company. Paired with GMP manufacturing at translational institutes, this lets academic centres test conjugates against novel or rare-cancer antigens that no company will prioritise. The Structural Genomics Consortium's open chemical probes and the IAVI/Neutralizing Antibody Center model for HIV antibodies are precedents for open engineering infrastructure.
Shares The valley of death between lab and product, Bispecific antibodies, T-cell engagers (bispecific), Antibody-drug conjugate (ADC).
Shares Site-specific conjugation & linker chemistry, Antibody-drug conjugate (ADC).
Shares Regional translational institutes with academic GMP suites and IND teams, The valley of death between lab and product.
Shares Site-specific conjugation & linker chemistry, Antibody-drug conjugate (ADC).
Shares Site-specific conjugation & linker chemistry, Antibody-drug conjugate (ADC).