The Indian company whose trispecific antibody ISB 2001 for multiple myeloma was licensed to AbbVie in 2025 for 700 million dollars upfront, the largest deal for an Indian-discovered cancer drug.
Glenmark was founded on 18 November 1977 by Gracias Saldanha in Mumbai. In January 2024 it consolidated oncology discovery into Ichnos Glenmark Innovation (IGI), a venture with its subsidiary Ichnos Sciences, with three molecules in the clinic at launch. In July 2025 IGI licensed ISB 2001, a BCMA x CD38 x CD3 trispecific T-cell engager in phase 1 for relapsed or refractory multiple myeloma, to AbbVie for 700 million dollars upfront and up to 1.225 billion dollars in milestones plus royalties; AbbVie took North America, Europe, Japan and Greater China and Glenmark kept India and emerging markets. In 2025 Glenmark also in-licensed the HER2 ADC trastuzumab rezetecan from Hengrui (a deal valued at up to 1.1 billion dollars) and the EGFR inhibitor aumolertinib from Hansoh for several regions.
An Indian-discovered antibody that grips two targets on myeloma cells at once while pulling in T cells to kill them, licensed to AbbVie in 2025 in the biggest deal yet for an Indian cancer drug.
Hengrui's HER2 ADC, approved in China for lung cancer and showing Enhertu-scale results in breast cancer, part of a wave of Chinese ADCs heading for global trials.
Shares CD38, Bispecific antibodies, T-cell engagers (bispecific), Multiple myeloma.
Shares Trastuzumab rezetecan, Jiangsu Hengrui Pharmaceuticals, Antibody-drug conjugate (ADC).
Shares Trastuzumab rezetecan, Jiangsu Hengrui Pharmaceuticals, Antibody-drug conjugate (ADC).
Shares Bispecific antibodies, T-cell engagers (bispecific), Multiple myeloma.
Shares CD38, BCMA, Bispecific antibodies, T-cell engagers (bispecific).
Shares ISB 2001, Multiple myeloma.
Shares Trastuzumab rezetecan, Jiangsu Hengrui Pharmaceuticals, Antibody-drug conjugate (ADC).
Shares The valley of death between lab and product, Bispecific antibodies, T-cell engagers (bispecific), Antibody-drug conjugate (ADC).