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Most cancer cells that spread die or sleep forever; a few grow into lethal metastases. Nobody can yet tell them apart, and doing so would show whom to treat after surgery.
This open question asks what decides which disseminated cancer cells ever colonise: most die or sleep forever, a few grow into lethal metastases, and nobody can yet tell them apart. Bone marrow Disseminated tumour cells (DTCs) are common yet Late recurrence is uncommon; candidates include stemness programmes, niche interactions, immune surveillance and stochastic awakening (see Tumour dormancy). The hypothesis is that a measurable DTC state at surgery predicts late metastasis independently of stage and could be targeted with dormancy-enforcing therapy. The test is single-cell DTC profiling plus serial ctDNA in stage II-III breast cancer, relevant to HR-positive / HER2-negative breast cancer, Triple-negative breast cancer (TNBC) and Prostate cancer.
Shares Late recurrence, The Mount Sinai Hospital / Tisch Cancer Institute, Tumour dormancy, The metastatic cascade and the tags mechanism, open-question.
Shares Single-cell & spatial profiling, Memorial Sloan Kettering Cancer Center and the tags mechanism, open-question.
Shares Memorial Sloan Kettering Cancer Center, Prostate cancer and the tags mechanism, open-question.
Shares Cold Spring Harbor Laboratory and the tags mechanism, open-question.
Shares Memorial Sloan Kettering Cancer Center, Prostate cancer and the tags mechanism, open-question.
Shares Memorial Sloan Kettering Cancer Center, Triple-negative breast cancer (TNBC) and the tags mechanism, open-question.
Shares Memorial Sloan Kettering Cancer Center, Triple-negative breast cancer (TNBC) and the tags mechanism, open-question.
Shares Memorial Sloan Kettering Cancer Center and the tags mechanism, open-question.