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Peginterferon alfa-2b, a long-acting interferon, was approved in 2011 as Sylatron for melanoma that had spread to lymph nodes and been removed, to delay recurrence; checkpoint inhibitors have since replaced it in that role.
Peginterferon alfa-2b was first approved in 2000 for chronic hepatitis C. The Sylatron formulation gained FDA approval in 2011 for adjuvant treatment of melanoma with microscopic or gross nodal involvement within 84 days of complete resection, based on the EORTC 18991 trial, in which five years of weekly injections improved relapse-free but not overall survival. Fatigue, depression and liver enzyme rises made most patients stop early. Adjuvant pembrolizumab, nivolumab and dabrafenib with trametinib have superseded interferon in resected stage III melanoma, and Sylatron was discontinued.
Interferon alfa-2b with a polyethylene glycol chain that slows clearance; it signals through IFNAR to stimulate immune cells and slow tumour growth. Connects to Interferon alpha receptor (IFNAR1).
1.Peginterferon alfa-2b binds Interferon alpha receptor (IFNAR1).
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| Region | Year | Indication |
|---|---|---|
| US | 2011 | Adjuvant treatment of melanoma with nodal involvement after complete resection (Sylatron) · Discontinued; superseded by adjuvant checkpoint and targeted therapy |
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Query for this drug: (TITLE:"Peginterferon alfa-2b" OR ABSTRACT:"Peginterferon alfa-2b" OR TITLE:"Sylatron" OR ABSTRACT:"Sylatron" OR TITLE:"PegIntron" OR ABSTRACT:"PegIntron") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Peginterferon alfa-2b, not a curated reading list.
Shares Cytokines & engineered cytokines and the tag chembl-universe.
Shares Cytokines & engineered cytokines and the tag chembl-universe.
Shares Cytokines & engineered cytokines and the tag chembl-universe.
Shares Cytokines & engineered cytokines and the tag chembl-universe.
Shares Melanoma and the tag chembl-universe.
Shares Essential thrombocythaemia (ET), Polycythaemia vera (PV), Primary myelofibrosis.
Shares Essential thrombocythaemia (ET), Interferon alfa-2a/2b, Polycythaemia vera (PV), Primary myelofibrosis.
Shares Essential thrombocythaemia (ET), Polycythaemia vera (PV), Cytokines & engineered cytokines.