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Lenograstim is Europe's and Japan's glycosylated form of G-CSF, given after chemotherapy to shorten the period of dangerously low neutrophils and to mobilise stem cells for transplant; it does the same job as filgrastim.
Lenograstim is granulocyte colony-stimulating factor made in Chinese hamster ovary cells, so it carries the sugar chain of the natural protein, unlike filgrastim made in E. coli. It has been approved in Europe and Japan since the early 1990s to reduce the duration of neutropenia after cytotoxic chemotherapy and bone marrow transplantation and to mobilise peripheral blood stem cells in patients and healthy donors. Trials comparing it with filgrastim show equivalent efficacy at comparable doses. It was never approved in the United States.
Activates the G-CSF receptor on neutrophil precursors to drive their proliferation, maturation and release from the marrow. Connects to G-CSF receptor (CSF3R).
1.Lenograstim slips into a pocket on G-CSF receptor (CSF3R).
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Query for this drug: (TITLE:"Lenograstim" OR ABSTRACT:"Lenograstim" OR TITLE:"Granocyte" OR ABSTRACT:"Granocyte" OR TITLE:"rHuG-CSF glycosylated" OR ABSTRACT:"rHuG-CSF glycosylated") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Lenograstim, not a curated reading list.
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Shares Filgrastim (G-CSF), Cytokines & engineered cytokines and the tag chembl-universe.
Shares Filgrastim (G-CSF) and the tag chembl-universe.
Shares Cytokines & engineered cytokines and the tag chembl-universe.
Shares Cytokines & engineered cytokines and the tag chembl-universe.
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Shares Pegfilgrastim, Filgrastim (G-CSF).
Shares Pegfilgrastim, Filgrastim (G-CSF).