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Akynzeo combines two anti-sickness drugs in one capsule or infusion taken once before chemotherapy, so a single dose plus dexamethasone protects against both immediate and delayed vomiting.
Netupitant/palonosetron was approved by the FDA in October 2014 for prevention of acute and delayed nausea and vomiting with initial and repeat courses of chemotherapy including highly emetogenic regimens, in combination with dexamethasone, on phase 3 trials against palonosetron alone in cisplatin and anthracycline-cyclophosphamide regimens in which complete response over five days was higher, a statistically significant difference; the intravenous fosnetupitant/palonosetron formulation followed in 2018. The EU authorised Akynzeo in 2015. It simplifies the guideline-recommended triple regimen to one antiemetic product plus a steroid. Headache, asthenia and constipation are the main adverse effects; netupitant is a moderate CYP3A4 inhibitor.
Netupitant, a long-acting substance P/NK1 receptor antagonist, blocks delayed emesis while palonosetron, a 5-HT3 antagonist, covers the acute phase; a single capsule or infusion with dexamethasone.
1.Netupitant and palonosetron slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 2014 | Acute and delayed chemotherapy-induced nausea and vomiting including highly emetogenic regimens, with dexamethasone (intravenous form 2018) |
| EU | 2015 | Acute and delayed nausea and vomiting with highly and moderately emetogenic chemotherapy (Akynzeo) |
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Query for this drug: (TITLE:"Netupitant and palonosetron" OR ABSTRACT:"Netupitant and palonosetron" OR TITLE:"Akynzeo" OR ABSTRACT:"Akynzeo" OR TITLE:"NEPA" OR ABSTRACT:"NEPA" OR TITLE:"Fosnetupitant and palonosetron intravenous" OR ABSTRACT:"Fosnetupitant and palonosetron intravenous") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Netupitant and palonosetron, not a curated reading list.
Shares Antiemetics for chemotherapy-induced nausea and vomiting and the tag supportive.
Shares Antiemetics for chemotherapy-induced nausea and vomiting and the tag supportive.
Shares Aprepitant (and fosaprepitant), Palonosetron, Antiemetics for chemotherapy-induced nausea and vomiting and the tag supportive.
Shares Palonosetron, Antiemetics for chemotherapy-induced nausea and vomiting and the tag supportive.
Shares Helsinn, Aprepitant (and fosaprepitant), Palonosetron, Antiemetics for chemotherapy-induced nausea and vomiting.
Shares Safety and Antiemetic Efficacy of Akynzeo Plus Dexamethasone During Radiotherapy and Concomitant Weekly Cisplatin, Treatment of Refractory Nausea and Vomiting in Patients With Breast Cancer, NK1 receptor (TACR1), Aprepitant (and fosaprepitant) and the tag supportive.
Shares NK1 receptor (TACR1), Palonosetron.