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Granisetron is an anti-sickness medicine for chemotherapy given as a tablet, an injection, a week-long skin patch (Sancuso) or a slow-release injection that lasts several days (Sustol).
Granisetron (Kytril) was approved in December 1993 for prevention of nausea and vomiting from emetogenic chemotherapy, with tablets and a radiotherapy indication following; oral and intravenous granisetron are now generic. Two formulations extended its reach: the Sancuso transdermal patch (2008) applied 24 to 48 hours before chemotherapy and worn for up to seven days for regimens of up to five consecutive days, and Sustol (2016), a polymer-based extended-release subcutaneous injection that maintains levels for at least five days and is approved with other antiemetics for acute and delayed nausea and vomiting after moderately emetogenic or anthracycline-cyclophosphamide chemotherapy. The EU authorised Sancuso in 2012. Headache and constipation are the class effects; QT prolongation is less than with dolasetron.
Selective serotonin 5-HT3 receptor antagonist acting on vagal afferents in the gut and the chemoreceptor trigger zone.
1.Granisetron slips into a pocket on its target.
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| Region | Year | Indication |
|---|---|---|
| US | 1993 | Prevention of nausea and vomiting from emetogenic chemotherapy (Kytril; radiotherapy later) |
| US | 2008 | Transdermal system for chemotherapy of up to five consecutive days (Sancuso) |
| US | 2016 | Extended-release injection for acute and delayed nausea and vomiting with moderately emetogenic or anthracycline-cyclophosphamide chemotherapy (Sustol) |
| EU | 2012 | Transdermal granisetron for moderately or highly emetogenic chemotherapy (Sancuso) |
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Query for this drug: (TITLE:"Granisetron" OR ABSTRACT:"Granisetron" OR TITLE:"Kytril" OR ABSTRACT:"Kytril" OR TITLE:"historic" OR ABSTRACT:"historic" OR TITLE:"Sancuso" OR ABSTRACT:"Sancuso" OR TITLE:"Sustol" OR ABSTRACT:"Sustol" OR TITLE:"Granisetron hydrochloride" OR ABSTRACT:"Granisetron hydrochloride") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Granisetron, not a curated reading list.
Shares Heron Therapeutics, Ondansetron, Palonosetron, Antiemetics for chemotherapy-induced nausea and vomiting and the tag supportive.
Shares Study 3 (rolapitant, moderately emetogenic chemotherapy), Antiemetics for chemotherapy-induced nausea and vomiting and the tags supportive, generic.
Shares the tags supportive, generic.
Shares the tags supportive, generic.
Shares the tags supportive, generic.
Shares the tags supportive, generic.
Shares the tags supportive, generic.
Shares Study 3 (rolapitant, moderately emetogenic chemotherapy), Antiemetics for chemotherapy-induced nausea and vomiting and the tag supportive.