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Histrelin is a GnRH agonist delivered by a small implant under the skin of the arm that lasts a whole year, approved in the United States as Vantas for palliative treatment of advanced prostate cancer and as Supprelin for early puberty in children.
Histrelin acetate was first approved in the United States in 1991 as a daily injection for central precocious puberty. The Vantas hydrogel implant, approved in 2004, releases the drug for twelve months and was labelled for palliative treatment of advanced prostate cancer, suppressing testosterone as effectively as monthly or three-monthly leuprolide with one minor procedure a year. Vantas was discontinued in 2021 after manufacturing problems, while the Supprelin LA implant for children continues. Hot flushes, fatigue and the class effects of androgen deprivation apply.
Ball-and-stick model from PubChem 2D record (no 3D conformer available). PubChem record
A potent GnRH analogue that, given continuously, desensitises the pituitary so luteinising hormone and testosterone fall to castrate levels after an initial surge. Connects to GnRH receptor (GNRHR).
1.Histrelin binds GnRH receptor (GNRHR).
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Query for this drug: (TITLE:"Histrelin" OR ABSTRACT:"Histrelin" OR TITLE:"Vantas" OR ABSTRACT:"Vantas" OR TITLE:"Supprelin LA" OR ABSTRACT:"Supprelin LA" OR TITLE:"Histrelin acetate" OR ABSTRACT:"Histrelin acetate") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Histrelin, not a curated reading list.
Shares GnRH receptor (GNRHR), Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial, Goserelin / leuprolide (ovarian function suppression), Leuprolide (leuprorelin) and GnRH agonists and the tag chembl-universe.
Shares GnRH receptor (GNRHR), Leuprolide (leuprorelin) and GnRH agonists, Endocrine therapy (SERMs, AIs, SERDs), Prostate cancer and the tag chembl-universe.
Shares Endocrine therapy (SERMs, AIs, SERDs), Prostate cancer and the tag chembl-universe.
Shares Endocrine therapy (SERMs, AIs, SERDs), Prostate cancer and the tag chembl-universe.
Shares Endocrine therapy (SERMs, AIs, SERDs) and the tag chembl-universe.
Shares Endocrine therapy (SERMs, AIs, SERDs) and the tag chembl-universe.
Shares Prostate cancer and the tag chembl-universe.
Shares Prostate cancer and the tag chembl-universe.