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These are fast-acting forms of the opioid fentanyl, taken as a tablet against the cheek or as a nasal spray, for sudden flares of pain in people whose cancer pain is otherwise controlled by a regular opioid. They are only for patients already tolerant to opioids.
Three centrally authorised fentanyl products are indicated for breakthrough pain in adults who are already receiving maintenance opioid therapy for chronic cancer pain, breakthrough pain being a transitory exacerbation on a background of otherwise controlled persistent pain: Effentora buccal tablets (authorised 4 April 2008; marketing authorisation holder Phoenix Labs Unlimited Company), Instanyl nasal spray (authorised 20 July 2009; Istituto Gentili S.r.l.) and PecFent nasal spray (authorised 31 August 2010; Gruenenthal GmbH). The EMA lists the therapeutic area as pain. This record covers the cancer-pain formulations only.
Mu-opioid receptor agonist formulated for fast absorption through the mouth or nose, for breakthrough pain in adults already on maintenance opioid therapy for chronic cancer pain (indication wording, EMA). Connects to Mu-opioid receptor.
1.Fentanyl (transmucosal, for breakthrough cancer pain) slips into a pocket on Mu-opioid receptor.
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| Region | Year | Indication |
|---|---|---|
| EU | 2008 | Breakthrough pain in adults receiving maintenance opioid therapy for chronic cancer pain · Effentora authorised 4 Apr 2008 (Phoenix Labs); Instanyl 20 Jul 2009 (Istituto Gentili); PecFent 31 Aug 2010 (Gruenenthal) |
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Query for this drug: (TITLE:"Fentanyl" OR ABSTRACT:"Fentanyl" OR TITLE:"transmucosal, for breakthrough cancer pain" OR ABSTRACT:"transmucosal, for breakthrough cancer pain" OR TITLE:"Effentora" OR ABSTRACT:"Effentora" OR TITLE:"Instanyl" OR ABSTRACT:"Instanyl" OR TITLE:"PecFent" OR ABSTRACT:"PecFent" OR TITLE:"fentanyl" OR ABSTRACT:"fentanyl") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Fentanyl (transmucosal, for breakthrough cancer pain), not a curated reading list.
Shares the tags ema-register, supportive.
Shares the tags ema-register, supportive.
Shares the tags ema-register, supportive.
Shares Cancer pain management and the tag supportive.
Shares Mu-opioid receptor, Methylnaltrexone, Cancer pain management and the tag supportive.
Shares Cancer pain management and the tag supportive.
Shares Cancer pain management and the tag supportive.
Shares Cancer pain management and the tag supportive.