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ALLO-647 is an experimental monoclonal antibody from Allogene Therapeutics in phase 2 trials for diffuse large B-cell lymphoma, aimed at CD52.
ALLO-647 is a monoclonal antibody developed by Allogene Therapeutics. Its target is CD52 (the sponsor names CD52). The sponsor states: Monoclonal antibody that recognises the CD52 antigen; used as part of a lymphodepletion regimen (with fludarabine and cyclophosphamide) ahead of allogeneic CAR T-cell dosing. ClinicalTrials.gov describes the intervention as: ALLO-647 is a monoclonal antibody that recognizes a CD52 antigen. It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, in diffuse large B-cell lymphoma. The largest, NCT04416984, plans to enrol 160 participants with primary completion expected 2029-02. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.
Monoclonal antibody that recognises the CD52 antigen; used as part of a lymphodepletion regimen (with fludarabine and cyclophosphamide) ahead of allogeneic CAR T-cell dosing. Connects to CD52.
1.ALLO-647 binds CD52.
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Query for this drug: (TITLE:"ALLO-647" OR ABSTRACT:"ALLO-647") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ALLO-647, not a curated reading list.
Shares Allogene Therapeutics, Diffuse large B-cell lymphoma and the tag pipeline.
Shares Diffuse large B-cell lymphoma and the tag pipeline.
Shares Diffuse large B-cell lymphoma and the tag pipeline.
Shares Diffuse large B-cell lymphoma and the tag pipeline.
Shares Diffuse large B-cell lymphoma and the tag pipeline.
Shares Diffuse large B-cell lymphoma and the tag pipeline.
Shares Diffuse large B-cell lymphoma and the tag pipeline.
Shares Diffuse large B-cell lymphoma and the tag pipeline.