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The receptor through which interferon alpha alerts immune cells and slows tumour growth. Interferon was one of the first immunotherapies, used in melanoma, hairy cell leukaemia and chronic myeloid leukaemia, and has largely given way to targeted drugs and checkpoint inhibitors. This dossier gathers the 1 product (0 approved), 2 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Subunit of the type I interferon receptor signalling through JAK1, TYK2 and STAT1/STAT2 to induce interferon-stimulated genes.
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Metastatic cancer | immune% | Immune-cell target (interferon alpha receptor on immune and tumour cells alike): expressed on immune cells rather than on the tumour, so patient selection rests on the cancer type and, in trials, on PD-L1 or immune biomarkers. |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
| Modality | Withdrawn or failed |
|---|---|
| Pegylated type I interferon, weekly subcutaneous injection 1 |
| Trial | Setting | Result | Products | ||
|---|---|---|---|---|---|
| 3 | Completed | Danish Study of Low-dose Interferon Alpha Versus Hydroxyurea in the Treatment of Philadelphia Chromosome Negative (Ph-)Chronic Myeloid Neoplasms. | - | ||
| 2 | Active | Phase II Study Incorporating Pegylated Interferon In the Treatment For Children With High-Risk Melanoma | - |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"Interferon alpha receptor" OR ABSTRACT:"Interferon alpha receptor" OR TITLE:"IFNAR1" OR ABSTRACT:"IFNAR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Interferon alpha receptor (IFNAR1), not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/ifnar1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ifnar1.json. Licence CC BY-NC 4.0.