{"id":"ifnar1","name":"Interferon alpha receptor (IFNAR1)","symbol":"IFNAR1","route":"/targets/ifnar1/","asOf":"2026-09-04","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5432","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000142166","uniprot":"https://www.uniprot.org/uniprotkb/P17181/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P17181","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL1887","open-targets":"https://platform.opentargets.org/target/ENSG00000142166","civic":"https://civicdb.org/genes/3454/summary","oncokb":"https://www.oncokb.org/gene/IFNAR1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=IFNAR1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=IFNAR1","depmap":"https://depmap.org/portal/gene/IFNAR1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000142166-IFNAR1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/3454","omim":"https://www.omim.org/entry/107450"}],"products":[{"id":"peginterferon-alfa-2b","name":"Peginterferon alfa-2b","status":"established","modality":"Pegylated type I interferon, weekly subcutaneous injection","route":"/drugs/peginterferon-alfa-2b/"}],"trials":[{"id":"nct01387763","name":"A Study of Low Dose Interferon Alpha Versus Hydroxyurea in Treatment of Chronic Myeloid Neoplasms","nct":"NCT01387763","phase":"3","status":"completed"},{"id":"nct00539591","name":"Phase II Study Incorporating Pegylated Interferon In the Treatment For Children With High-Risk Melanoma","nct":"NCT00539591","phase":"2","status":"active"}],"pathways":[],"companies":["merck"],"keyPapers":["paper-darnell-jak-stat-science-1994"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}