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Trials
A Study of HDM2005 in Combination With Standard of Care in Patients With Diffuse Large B-Cell Lymphoma

trialsTrialRecruiting

A Study of HDM2005 in Combination With Standard of Care in Patients With Diffuse Large B-Cell Lymphoma

A phase 1/2 trial of Gemcitabine, CAPOX, Cyclophosphamide in diffuse large b-cell lymphoma, run by Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd., now recruiting.

Overview Connected6

Overview

A Study of HDM2005 in Combination With Standard of Care in Patients With Diffuse Large B-Cell Lymphoma is a phase 1/2 interventional study registered as NCT07124936 by Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd., with 97 participants planned, started 2025-07-30 and due to reach its primary completion in 2027-10-26. Interventions recorded: HDM2005, Rituximab or Rituximab biosimilar, Gemcitabine, Oxaliplatin, Cyclophosphamide. Conditions listed: Diffuse Large B Cell Lymphoma (DLBCL). No results are recorded here; the registry entry is the source.

Setting

A Phase 1b/2 Study to Evaluate the Safety, Tolerability, and Antitumor Activity of HDM2005 in Combination With Standard of Care in Patients With Diffuse Large B-Cell Lymphoma

Phase

Phase 1/2

Sponsor

Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

Registry

Started

2025-07-30

Enrolled

97 enrolled

Connected

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cancers

Diffuse large B-cell lymphoma

drugs

ApprovedCytotoxic regimen

CAPOX (capecitabine, oxaliplatin)

ApprovedAlkylating agent (oxazaphosphorine prodrug)

Cyclophosphamide · Cytoxan / Endoxan

ApprovedCytotoxic chemotherapy (anthracycline)

Doxorubicin · Adriamycin

ApprovedNucleoside analogue (deoxycytidine)

Gemcitabine · Gemzar / Infugem

ApprovedGlucocorticoid

Prednisone · Deltasone (historic) / Rayos

Evidence strength23/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
97 enrolled+10
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-16 · Jude Gomila · Header signup, trial wave 5 and Ask weighting · diff · file

Sources & links

ClinicalTrials.gov NCT07124936

Data

JSON ·

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Cancers

Diffuse large B-cell lymphoma

Products

Gemcitabine
CAPOX (capecitabine, oxaliplatin)
Cyclophosphamide
Doxorubicin
Prednisone

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