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Trials
A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

trialsTrialRecruiting

A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

A phase 1/2 trial of Patritumab deruxtecan in advanced solid tumours, run by Merck Sharp & Dohme LLC, now recruiting.

Also called: LIGHTBEAM-U01

Overview Connected5

Overview

A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01) is a phase 1/2 interventional study registered as NCT06941272 by Merck Sharp & Dohme LLC, with 50 participants planned, started 2025-05-26 and due to reach its primary completion in 2030-12-30. Interventions recorded: Patritumab Deruxtecan.

Setting

LIGHTBEAM-U01 Substudy 01C: A Phase 1/2 Substudy to Evaluate the Safety and Efficacy of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors

Phase

Phase 1/2

Sponsor

Merck Sharp & Dohme LLC

Registry

Started

2025-05-26

Enrolled

50 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

Antibody-drug conjugate (ADC)

drugs

Phase 3ADC

Patritumab deruxtecan

companies

Daiichi Sankyo Merck & Co. (MSD)

Evidence strength16/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
50 enrolled+8
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT06941272

Data

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

Antibody-drug conjugate (ADC)

Products

Patritumab deruxtecan

Companies

Merck & Co. (MSD)
Daiichi Sankyo

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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