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Trials
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Rela

trialsTrialRecruiting

A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Rela

A phase 3 trial of Golcadomide, Rituximab, Lenalidomide in follicular lymphoma, run by Celgene, now recruiting.

Overview Connected10

Overview

A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4) is a phase 3 interventional study registered as NCT06911502 by Celgene, with 400 participants planned, started 2025-07-28 and due to reach its primary completion in 2028-04-24. Interventions recorded: Golcadomide, Rituximab, Lenalidomide, Cyclophosphamide, Doxorubicin. Conditions listed: Follicular Lymphoma. No results are recorded here; the registry entry is the source.

Setting

A Phase 3, Multicenter, Randomized, Open Label Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) Vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy

Phase

Phase 3

Sponsor

Celgene

Registry

Started

2025-07-28

Enrolled

400 enrolled

Connected

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cancers

Follicular lymphoma

technologies

Monoclonal antibodies PROTACs & molecular glues (targeted protein degradation)

drugs

ApprovedAlkylating agent (oxazaphosphorine prodrug)

Cyclophosphamide · Cytoxan / Endoxan

ApprovedCytotoxic chemotherapy (anthracycline)

Doxorubicin · Adriamycin

Phase 3Molecular glue degrader (CELMoD, IKZF1/3)

ApprovedImmunomodulatory drug (cereblon E3 ligase modulator)

Lenalidomide · Revlimid

ApprovedMonoclonal antibody (anti-CD20, chimeric)

Rituximab · Rituxan / MabThera (and biosimilars)

ApprovedVinca alkaloid (microtubule inhibitor)

Vincristine · Oncovin / Marqibo

companies

Bristol Myers Squibb

Evidence strength48/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
400 enrolled+13
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT06911502

Data

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Cancers

Follicular lymphoma

Technologies

Monoclonal antibodies
PROTACs & molecular glues (targeted protein degradation)

Products

Golcadomide
Rituximab
Lenalidomide
Cyclophosphamide
Doxorubicin
Vincristine

Companies

Bristol Myers Squibb

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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