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Trials
First-in-Human Investigation of JMT108 Injection in Participants With Advanced Malignant Tumors

trialsTrialRecruiting

First-in-Human Investigation of JMT108 Injection in Participants With Advanced Malignant Tumors

A phase 1/2 trial of Pembrolizumab and Ivonescimab in advanced solid tumours, run by Shanghai JMT-Bio Inc., now recruiting.

Overview Connected4

Overview

First-in-Human Investigation of JMT108 Injection in Participants With Advanced Malignant Tumors is a phase 1/2 interventional study registered as NCT06877650 by Shanghai JMT-Bio Inc., with 436 participants planned, started 2025-04-11 and due to reach its primary completion in 2028-03-30. Interventions recorded: JMT108, Pembrolizumab and Ivonescimab.

Setting

A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-tumor Activity of JMT108 Injection in Participants With Advanced Malignant Tumors.

Phase

Phase 1/2

Sponsor

Shanghai JMT-Bio Inc.

Registry

Started

2025-04-11

Enrolled

436 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

ApprovedBispecific antibody (PD-1×VEGF)

ApprovedMonoclonal antibody (anti-PD-1)

Pembrolizumab · Keytruda / Keytruda Qlex (SC)

companies

CSPC Pharmaceutical Group

Evidence strength26/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
436 enrolled+13
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-16 · Jude Gomila · Registry trials wave 6 and products wave 7 · diff · file

Sources & links

ClinicalTrials.gov NCT06877650

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Products

Pembrolizumab
Ivonescimab

Companies

CSPC Pharmaceutical Group

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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