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Trials
First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma

trialsTrialRecruiting

First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma

A phase 1/2 trial of Antibody-drug conjugate (ADC) in sarcomas, run by Adcendo ApS, now recruiting.

Also called: ADCElerate1

Overview Connected4

Overview

First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma is a phase 1/2 interventional study registered as NCT06797999 by Adcendo ApS, with 270 participants planned, started 2025-06-05 and due to reach its primary completion in 2029-02-27. Interventions recorded: Antibody-drug conjugate (ADC).

Setting

A First-in-human, Phase 1/2, Multicenter, Open-label, Dose Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of ADCE-D01, a Humanized Anti-human uPARAP Antibody Linked to a Topoisomerase I Inhibitor, in Patients With Metastatic and/or Unresectable Soft Tissue Sarcoma

Phase

Phase 1/2

Sponsor

Adcendo ApS

Registry

Started

2025-06-05

Enrolled

270 enrolled

Connected

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cancers

Sarcomas (soft tissue, bone, GIST)

technologies

Antibody-drug conjugate (ADC)

targets

Topoisomerase I (TOP1)

companies

Evidence strength20/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
270 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Add 115 registry trial acronyms from the CT.gov acronym f… · diff · file

Sources & links

ClinicalTrials.gov NCT06797999

Data

JSON ·

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Cancers

Sarcomas (soft tissue, bone, GIST)

Technologies

Antibody-drug conjugate (ADC)

Targets

Topoisomerase I (TOP1)

Companies

Adcendo

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id nct06797999.

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