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Trials
A Study of RNK08954 in Subjects With Advanced Solid Tumors With KRAS ((Kirsten Rat Sarcoma) G12D Mutation

trialsTrialRecruiting

A Study of RNK08954 in Subjects With Advanced Solid Tumors With KRAS ((Kirsten Rat Sarcoma) G12D Mutation

A phase 1/2 trial of RNK08954-01 in sarcomas, run by Ranok Therapeutics (Hangzhou) Co., Ltd., now recruiting.

Also called: TRIAD1

Overview Connected3

Overview

A Study of RNK08954 in Subjects With Advanced Solid Tumors With KRAS ((Kirsten Rat Sarcoma) G12D Mutation is a phase 1/2 interventional study registered as NCT06667544 by Ranok Therapeutics (Hangzhou) Co., Ltd., with 152 participants planned, started 2024-11-08 and due to reach its primary completion in 2026-12. Interventions recorded: RNK08954-01.

Setting

A Phase 1/2, First-in-Human, Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of RNK08954 in Patients With Advanced Solid Tumors With a KRAS G12D Mutation TRIAD1 (Trial of RNK08954 In KRAS G12D Mutation)

Phase

Phase 1/2

Sponsor

Ranok Therapeutics (Hangzhou) Co., Ltd.

Registry

Started

2024-11-08

Enrolled

152 enrolled

Connected

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cancers

Sarcomas (soft tissue, bone, GIST)

targets

companies

Ranok Therapeutics (Hangzhou)

Evidence strength19/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
152 enrolled+11
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Add 115 registry trial acronyms from the CT.gov acronym f… · diff · file

Sources & links

ClinicalTrials.gov NCT06667544

Data

JSON ·

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Cancers

Sarcomas (soft tissue, bone, GIST)

Targets

KRAS

Companies

Ranok Therapeutics (Hangzhou)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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