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Trials
A Study of Duvelisib Versus Gemcitabine or Bendamustine in Participants With Relapsed/Refractory Nodal T Cell Lymphoma With T Follicular Helper (TFH) Phenotype

trialsTrialRecruiting

A Study of Duvelisib Versus Gemcitabine or Bendamustine in Participants With Relapsed/Refractory Nodal T Cell Lymphoma With T Follicular Helper (TFH) Phenotype

A phase 3 trial of Duvelisib, Gemcitabine and Bendamustine in non-Hodgkin lymphoma, run by SecuraBio, now recruiting.

Also called: TERZO

Overview Connected8

Overview

A Study of Duvelisib Versus Gemcitabine or Bendamustine in Participants With Relapsed/Refractory Nodal T Cell Lymphoma With T Follicular Helper (TFH) Phenotype is a phase 3 interventional study registered as NCT06522737 by SecuraBio, with 124 participants planned, started 2025-05-19 and due to reach its primary completion in 2028-02. Interventions recorded: Duvelisib, Gemcitabine and Bendamustine.

Setting

A Multicentre, Open-label, Phase 3, Randomised Controlled Trial of Duvelisib Versus Investigator's Choice of Gemcitabine or Bendamustine in Patients With Relapsed/Refractory Nodal T Cell Lymphoma With T Follicular Helper (TFH) Phenotype

Phase

Phase 3

Sponsor

SecuraBio

Registry

Started

2025-05-19

Enrolled

124 enrolled

Connected

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cancers

Nodal T-follicular helper cell lymphoma, angioimmunoblastic type (angioimmunoblastic T-cell lymphoma)Non-Hodgkin lymphoma (all types)

technologies

Cytotoxic chemotherapy Small-molecule kinase inhibitors

drugs

ApprovedAlkylating agent (nitrogen mustard-purine hybrid)

Bendamustine · Treanda / Bendeka / Belrapzo

ApprovedSmall-molecule PI3Kδ/γ inhibitor

Duvelisib · Copiktra

ApprovedNucleoside analogue (deoxycytidine)

Gemcitabine · Gemzar / Infugem

companies

Evidence strength45/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
124 enrolled+10
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT06522737

Data

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Cancers

Non-Hodgkin lymphoma (all types)

Technologies

Cytotoxic chemotherapy
Small-molecule kinase inhibitors

Products

Duvelisib
Gemcitabine
Bendamustine

Companies

SecuraBio

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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