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Trials
Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell Carcinoma

trialsTrialRecruiting

Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell Carcinoma

A phase 1/2 trial of Pembrolizumab in head and neck squamous cell carcinoma, run by Nykode Therapeutics ASA, now recruiting.

Overview Connected5

Overview

Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell Carcinoma is a phase 1/2 interventional study registered as NCT06016920 by Nykode Therapeutics ASA, with 110 participants planned, started 2023-12-19 and due to reach its primary completion in 2029-01. Interventions recorded: VB10.16 and Pembrolizumab.

Setting

A Phase 1/2, Open-label Trial to Evaluate Safety, Immunogenicity, and Anti-tumor Activity of VB10.16 in Combination With Pembrolizumab in Patients With Unresectable Recurrent or Metastatic HPV16-positive Head and Neck Squamous Cell Carcinoma

Phase

Phase 1/2

Sponsor

Nykode Therapeutics ASA

Registry

Started

2023-12-19

Enrolled

110 enrolled

Connected

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cancers

Head and neck squamous cell carcinoma Recurrent or metastatic head and neck squamous cell carcinoma

technologies

Immune checkpoint inhibitors

drugs

ApprovedMonoclonal antibody (anti-PD-1)

Pembrolizumab · Keytruda / Keytruda Qlex (SC)

companies

Merck & Co. (MSD)

Evidence strength23/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
110 enrolled+10
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT06016920

Data

JSON ·

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Cancers

Head and neck squamous cell carcinoma
Recurrent or metastatic head and neck squamous cell carcinoma

Technologies

Immune checkpoint inhibitors

Products

Pembrolizumab

Companies

Merck & Co. (MSD)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id nct06016920.

WebMCP tools registered on this page: onco_search, onco_get_entity.