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Trials
Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Gastric Cancer

trialsTrialActive

Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Gastric Cancer

A phase 2 trial of AST-301 in gastric & gastro-oesophageal junction cancer, run by Aston Sci. Inc., active and no longer recruiting.

Also called: CORNERSTONE-003

Overview Connected3

Overview

Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Gastric Cancer is a phase 2 interventional study registered as NCT05771584 by Aston Sci. Inc., with 24 participants enrolled, started 2023-07-04 and due to reach its primary completion in 2027-02-09. Interventions recorded: AST-301 and rhuGM-CSF.

Setting

A Phase 2 Study to Evaluate the Safety and Immunological Efficacy of Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Patients With HER2 Expressing Gastric Cancer (CORNERSTONE-003)

Phase

Phase 2

Sponsor

Aston Sci. Inc.

Registry

Started

2023-07-04

Enrolled

24 enrolled

Connected

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cancers

Gastric & gastro-oesophageal junction cancer HER2-positive gastric cancer

targets

Evidence strength22/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
24 enrolled+7
No structured primary endpoint0
Result: active0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Trial acronyms for registry records · diff · file

Sources & links

ClinicalTrials.gov NCT05771584

Data

JSON ·

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Cancers

Gastric & gastro-oesophageal junction cancer
HER2-positive gastric cancer

Targets

HER2

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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