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Trials
KN026 in Combination With Chemotherapy in HER2 Positive Gastric Cancer Subjects Who Have Failed First-line Therapy

trialsTrialRecruiting

KN026 in Combination With Chemotherapy in HER2 Positive Gastric Cancer Subjects Who Have Failed First-line Therapy

A phase 2/3 trial of Docetaxel in gastric & gastro-oesophageal junction cancer, run by Shanghai JMT-Bio Inc., now recruiting.

Overview Connected5

Overview

KN026 in Combination With Chemotherapy in HER2 Positive Gastric Cancer Subjects Who Have Failed First-line Therapy is a phase 2/3 interventional study registered as NCT05427383 by Shanghai JMT-Bio Inc., with 286 participants planned, started 2022-04-07 and due to reach its primary completion in 2025-11. Interventions recorded: KN026/Placbo Injection, Paclitaxel Injection, Docetaxel Injection and Irinotecan Injection.

Setting

A Randomized, Multicenter, Phase Ⅱ/Ш Clinical Study to Evaluate the Efficacy of KN026 in Combination With Chemotherapy in Subjects With HER2 Positive Advanced Unresectable or Metastatic Gastric Cancer (Including Gastro-esophageal Junction Adenocarcinoma) Who Have Failed First-line Therapy.

Phase

Phase 2/3

Sponsor

Shanghai JMT-Bio Inc.

Registry

Started

2022-04-07

Enrolled

286 enrolled

Connected

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cancers

Gastric & gastro-oesophageal junction cancer HER2-positive gastric cancer

technologies

Cytotoxic chemotherapy

drugs

ApprovedCytotoxic chemotherapy (taxane)

Docetaxel · Taxotere (generic)

companies

CSPC Pharmaceutical Group

Evidence strength39/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2/3+22
286 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT05427383

Data

JSON ·

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Cancers

Gastric & gastro-oesophageal junction cancer
HER2-positive gastric cancer

Technologies

Cytotoxic chemotherapy

Products

Docetaxel

Companies

CSPC Pharmaceutical Group

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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